In Categories: Economic Impact

Three thousand eight hundred. That’s the number of people diagnosed with type 2 diabetes each day in the United States [1]. Current estimates suggest there are over 30 million Americans with diabetes, and the economic burden has ballooned to over $320 billion [2].

Meanwhile, insulin prices have increased 197% in a recent 11-year period and continue to rise [3]. As a result, the cost of medications is a frequently-discussed topic in healthcare and economics broadly. The International Society for Pharmacoeconomics and Outcomes Research (ISPOR) listed “Drug Pricing and Spending” and the disconnect between cost and health value as the number one trend among their member experts. Until recently, there have been no real solutions that demonstrate an ability to either reverse the growth of diabetes prevalence or decelerate the rapidly growing economic burden.

Virta Health is changing this. We have previously released peer-reviewed results on our core type 2 diabetes outcomes: 60% of patients experienced diabetes reversala at 1 year and 94% of insulin users reduced or eliminated usageb [4], while most cardiovascular risk markers improved [5].

We now have additional insight into the cost savings generated by these results. This week, Virta was honored to present at ISPOR’s annual conference and provide additional data on the economic impact of the Virta Treatment. By tracking daily changes in prescriptions for each patient and using medication pricing aggregated from over 60,000 U.S pharmacies, we were able to identify reasonable estimates of the costs savings of our approach [6]:

  • Among the 218 “completers” in our clinical trial, the average annual expenditure on medications was reduced by 46% at one year versus baseline—over $2,000 less per person.
  • For the patients using insulin, the savings were even greater, totaling $4,337 in projected annual medication savings when comparing year 1 versus baseline. 49% of insulin users were able to eliminate usage entirelyb, while the average dosage among other insulin users was nearly cut in half [4].
  • Because medication reductions happened quickly, about 90% of savings were realized in year 1, with insulin reductions having the biggest impact.
  • Insulin wasn’t the only change. Sulfonylureas were completely eliminated thereby reducing the risk of hypoglycemic events. In fact, the Virta Treatment yielded medication reductions in 6 of 7 diabetes drug classes, where 3 of 6 were statistically significant. (The exception was GLP-1 agonists, which saw a non-statistically significant increase in this population from 12.8% to 13.8% [4]).

Figure 1: Annualized medication costs for patients who completed 1 year of the Virta Treatment. Mean costs declined 46% from $4,438 at baseline to $2,394 at 1 year. Cost reductions were rapid over the first two months. (14-day rolling average for completers. Mean – dark blue, S.E. – light blue.) [6]

Figure 2: Frequency of dosage changes (% of patients) at 1 year in various classes of diabetes medications. Only patients who completed 1 year of the Virta Treatment were included. [4]

What is incredibly exciting about these results is that they represent substantial savings, yet only include medication costs. When including other direct medical costs, our modeling efforts have shown that the Virta Treatment may generate an average of $9,600 in payer savings over the first two years.

Returning to ISPOR’s 2018 report on healthcare trends, interestingly, number two on the list was how “transformative treatments” are adding to budget pressures. Virta sits at an interesting intersection of these top healthcare industry concerns. Our outcomes are demonstrating that transformative health improvements can go hand-in-hand with cost reduction—a rare combination in healthcare.

We still have a long way to go before we reach our goal and help millions of people reverse type 2 diabetes, but we, along with our patients, are very encouraged by our outcomes thus far. Since day one of Virta, our team has embraced the responsibility of being science-and evidence-based, and we look forward to sharing additional health and economic outcomes with you along our journey.


[a] Of the 204 patients with HbA1c measurements at 1 year, 123 achieved HbA1c below the diagnostic threshold of 6.5% while taking no diabetes medications or metformin only.
[b] A total of 63 patients took insulin at some point in year 1. Of the 62 who started on insulin, by the end of the year, 31 had completely eliminated insulin and an additional 28 reduced their dosage.




  1. Avatar
    Jeanie Metzger May 24, 2018 at 7:51 pm

    Where can I find comprehensive nutritional charts to use for the program?


    1. Avatar

      Hi! We’re not sure what you mean by this. Can you clarify?


  2. Avatar

    My son has type 1 diabetes. Would your treatment work for him? At present he uses insulin.


    1. Avatar

      We don’t currently treat patients with type 1 diabetes, but you could talk to your physician about carbohydrate restriction for him. Here’s an article and a study on the topic:


  3. Avatar
    James McCarter May 26, 2018 at 3:40 pm

    Hi. Thanks for your question on T1D. Note that the Virta treatment is highly individualized and medical oversight is required. For type 1 diabetes (or any medical condition), please seek the care of a qualified physician who can provide support before making any dietary changes.

    I’d add that there is a description of our nutrition protocols in the Hallberg et al. 2018 paper materials and methods section (

    This commentary by senior author of the referenced 2018 Pediatrics paper Dr. David Ludwig of Harvard is also informative – – Note Dr. Ludwig’s advice “I STRONGLY CAUTION ANYONE WITH DIABETES TO DISCUSS ANY DIETARY CHANGES WITH HIS OR HER DIABETES CARE PROVIDER.”

    – Dr. Jim McCarter, Virta.


  4. Avatar

    What is Virta? I’ve never heard of it. I just started getting these emails out of the blue. The emails talk about Virta but I don’t find anything that says what it is or why I am receiving the emails.


    1. Avatar
      Eva Schulteis May 29, 2018 at 3:48 pm


      Thank you for reaching out. You can learn about how Virta works here:


Leave a reply

Your email address will not be published.